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  • 多肽定制产品过程中的盐类型的选择很重要
  • 本站编辑: 杭州肽佳生物科技有限公司发布日期:2020-01-08 17:31 浏览次数:

多肽定制产品的盐类型,不仅影响多肽的溶解性和稳定性,有时也具有部分生物毒性。所以选择合适的盐类型,对实验的成功至关重要。Supertide可以提供的盐类型有:

 The salt types of polypeptide products not only affect the solubility and stability of polypeptides, but also have partial biotoxicity. So choosing the right type of salt is crucial to the success of the experiment. The types of salt that Supertide can provide are

盐类型

特点或用途

三氟乙酸盐

TFA

多肽产品通常为三氟乙酸盐。由于三氟乙酸的生物毒性较大,部分实验需要避免此盐类型。

Polypeptide products are usually trifluoroacetate. Because of the high biotoxicity of trifluoroacetic acid, this salt type should be avoided in some experiments.

醋酸盐

Ac

由于醋酸的生物毒性小,大部分药物肽或美容肽为醋酸盐。但部分产品的醋酸盐稳定性不佳,需要考虑序列稳定性。

Because of the low biotoxicity of acetic acid, most drug peptides or beauty peptides are acetate. However, the acetate stability of some products is not good, so the sequence stability should be considered.

盐酸盐

HCl

较少产品会选择盐酸盐。部分序列由于特殊用途,需要采用盐酸盐

Less products will choose the hydrochloride. Some sequences require the use of hydrochloride for specific purposes

铵盐

NH4+

会严重影响产品的溶解性和稳定性,需要根据序列进行选择。

It will seriously affect the solubility and stability of the product, which needs to be selected according to the sequence.

钠盐

Na+

通常会影响产品的溶解性和稳定性

This usually affects the solubility and stability of the product

双羟萘酸盐

Pamoic acid

双羟萘酸盐通常用于多肽药物制作缓释剂

Dihydroxynaphthenate is commonly used in the production of peptide drugs as a sustained-release agent

柠檬酸盐

Citric Acid

生物毒性较小,但由于制备工艺较复杂,需要根据序列单独开发生产工艺

Biotoxicity is relatively low, but due to the complexity of the preparation process, it is necessary to develop the production process separately according to the sequence

水杨酸盐

Salicylic acid

影响多肽产品的稳定性,较少采用

Affect the stability of polypeptide products, less used